Archive puzzle
Doctordle #8
Persistent low mood and loss of interest
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Case notes
Sourced case summary
Open the full case notes after playing. The text is also rendered in the page HTML so search engines can understand the archived puzzle.
Case summary
This archived Doctordle case was published on 2026-04-08. It presents "Persistent low mood and loss of interest" as a Medium Psychiatry puzzle. The final answer is Major Depressive Disorder.
Answer
Major Depressive Disorder
Source
Topic pages verified on 2026-07-11
Information summarized from MedlinePlus.gov. MedlinePlus does not endorse Doctordle.
Six clues
Clue 1
A college student reports weeks of low mood and loss of interest.
Clue 2
Sleep is poor, appetite is reduced, and concentration has declined.
Clue 3
She feels guilty and slowed down most days.
Clue 4
There is no history of manic or hypomanic episodes in this fictional case.
Clue 5
The syndrome affects mood, thinking, and daily function.
Clue 6
The answer is a common depressive mood disorder.
Plain-language explanation
Major depressive disorder is a mood disorder associated with persistent low mood or loss of interest plus other symptoms that impair function. Any real thoughts of self-harm require urgent professional support.
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